Aditi Gupta
North Sydney,NSW
Summary
Skilled Researcher enthusiastic about supporting advancements in cell biology, immunology, oncology, recombinant technology, fermentation, drug discovery and microbiology. Passionate about increasing knowledge to drive growth and needed improvements. Ready to apply knowledge and six years of work experience in research.
Overview
7
7
years of professional experience
Work History
Production Manager
FuturePlace
10.2022 - 06.2023
- Direct client interaction
- Research and communication
- Project management
- Production management
- Program writing
- Time management
- Resolved issues quickly to maintain productivity goals
- Reviewed work for quality and compliance with company standards and design specifications
Research Scientist
Premas Biotech Pvt. Ltd
07.2019 - 06.2022
- Project management based on cell biology, immunology, recombinant proteins and antibodies, cell line development, drug discovery and oncology
- Study-plan, design, budget preparation and execution
- Bioassay development and bioreactor-based process development
- Direct interaction with international clients such as Zoetis and Cue Biopharma (U.S.)
- Data compilation, interpretation, or analysis
- Data presentation and report writing
- Research and Communication
- Team collaboration and management
- Team building
- Time and lab management
- SOP preparation according to regulatory standards
- Streamlined research processes to meet tight deadlines for multiple projects
- Provided qualified input and development support for the various study plans and protocols
- Wrote research papers, reports, and summaries regarding cell biology, immunology and recombinant proteins and antibodies
- Performed research into study topics to increase knowledge and to provide valuable contributions
Senior Associate Scientist
Venus Remedies Ltd
09.2016 - 07.2019
- Project management based on microbiology
- Medical writing
- Antibiotic validation
- Drug resistant microbes genetic study
- Team and time management
- Lab management
- SOP preparation
- Documented changes during experiments, noting unexpected issues arising during research activities
- Conducted experiments in laboratory environment for product development purposes
- Performed complex troubleshooting and assisted in leading initiatives to solve challenging scientific problems with assays or instrumentation
- Conducted moderately complex analysis to support process development
- Performed accurate quantitative analysis of targeted data research, collection and report preparation
Education
Ph.D. - Biotechnology
Shoolini University
06.2017
M.Sc. - Biotechnology
Panjab University
05.2012
B.Sc. - Biotechnology
Guru Nanak Dev University
05.2010
Skills
Technical skills
- Cell culture: Handling of CHO-S, CHO K1, CHODG44, Expi-CHO, Expi-293, 293FT, HEK-293, HL-60, A549, MCF-7, Hep-G2, Ramos, U266 cell lines & many more
- Shake flask-based scale-up study on CHO & HEK cells
- Media adaptation and feed studies
- Stable and transient transfection on CHO & HEK cell types using Lipofectamine 3000, Expifectamine, Electroporation (Neon Transfection) and Lentivirus mediated transfection (transfection & transduction) Stable cell pool & cell line generation
- Isolation of human PBMC and mouse/rat splenocytes
- 3D cell culture
- Cell-based assay: Cytotoxicity/ viability assay, co-culture microcytotoxicity assay, ADCC, CDC assay
- Bioassay development: Binding (protein-ligand, protein- protein) assay, stability assay, functionality assay
- Flow cytometry-based study & data analysis: Intracellular staining, multiple staining, cytokine production, protein binding, competitive binding, drug stability, cell population and cell apoptosis
- Upstream activity: Process development and handling of XRS (Pall's XRS System), Wave (Cytiva), Stirred (Sartorius system) bioreactors using CHO suspension cells up to 20 L culture volume with or without feed addition
- Analytical study: DNA/RNA/Protein isolation, SDS PAGE Electrophoresis, PCR/RT-PCR, Luminescence, Immunoblotting and ELISA
- Microbiology: Antibiotic susceptibility assay, MIC and FIC, Time-kill curve assay, development and validation of antimicrobial bioassay
Management skills
- Project management: Planning, costing or budgeting, study design, execution, data analysis & compliance
- Research and communication
- Direct Client Interaction: Interaction with international clients like Zoetis, Cue Biopharma (US)
- Team collaboration and management
- Team Building
- Analytical skills
- Troubleshooting
- Problem-solving
- Data presentation and report writing
- Planning and scheduling Time management
- Team work
- Business Development
- Cross-Functional Collaboration
- Equipment Operation
- Operational Efficiency
- Compliance with GMPs
- Safety and Sanitation Standards
- Training Skills
- Equipment Monitoring
- Operations Management
Research
Publications:
- Immunomodulatory activity of in vitro propagated tissues of Gentiana Kurroo Royle. International Journal of Biology, Pharmacy and Allied Sciences.4,1873-1886.
- Genomic and Functional Characterization of a Novel Burkholderia spp. Strain AU4i from Pea Rhizosphere Conferring Plant Growth Promoting Activities. Advancements in Genetic Engineering.4(3):129.
- Bioactive Fraction from Datura stramonium Linn. Promotes Human immune Cells Mediated Cytotoxicity towards Lung and Breast Cancer Cells. Pharmacognosy Journal. 8(5):435-439.
- Immunomodulation-mediated anticancer activity of a novel compound from Brugmansia suaveolens leaves. Bioorganic & Medical Chemistry. 28(12):115552.
- A triple antigen virus-like particle vaccine candidate against SARS CoV-2. Heliyon. 2021 Oct;7(10):e08124.
Timeline
Production Manager
FuturePlace
10.2022 - 06.2023
Research Scientist
Premas Biotech Pvt. Ltd
07.2019 - 06.2022
Senior Associate Scientist
Venus Remedies Ltd
09.2016 - 07.2019
Ph.D. - Biotechnology
Shoolini University
M.Sc. - Biotechnology
Panjab University
B.Sc. - Biotechnology
Guru Nanak Dev University
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