DEBORAH AUBIN
Research Officer 3 – Physiology/Physiopathology
Ultimo
Summary
Motivated and results-driven research officer with a PhD and extensive postdoctoral experience in stem cell research, gene therapy, and disease mechanisms. With a broad understanding of various cell types and therapeutic approaches.
Overview
14
14
years of professional experience
4
4
years of post-secondary education
2
2
Languages
Work History
Research Officer 3
Children Medical Research Institute
01.2022 - Current
- Gene Editing for Usher Syndrome Type 2A: Unravelling Photoreceptor Degeneration Mechanisms and Exploring Therapeutic Potential using Retinal organoids
Lead: Dr Anai Gonzalez-Cordero
Research Officer 1
Brainever – Collège de France
01.2020 - 01.2021
- Department of morphogenetic process: Homeoproteins and neurodegenerative disorders (ALS) - Using hiPSC derived motoneurons to understand ALS mechanism and treatment options.
Lead: Pr. Alain Prochiantz
PhD Fellowship
PHENOCELL – I-STEM
01.2014 - 01.2019
- Modelisation of Neurofibromatosis type 1 using human pluripotent stem cells and study of pathological mechanisms.
Lead: Dr Gilles Lemaitre and Dr Marc Pechansky at I-STEM - Dr Julien Maruotti and Dr Brigitte Onteniente at PHENOCELL
Research Assistant
INSERM
01.2013 - 01.2014
- Department of genetics and physiopathology of cerebrovascular diseases.
Lead: Dr Anne Joutel and Dr Elisabeth Tournier Lasserve
Research Internship
Sanofi
01.2013 - 12.2013
- Department of neurobiology: Exploratory Unit.
Lead: Dr Olivier Curet
Research Internship
Theranexus – CEA
01.2011 - 12.2012
- Treatment of neurological diseases and development of drug candidates modulating the interaction between neurons and glial cells.
Lead: Dr Mathieu Charvériat and Dr Frank Mouton
Education
Ph.D. - Physiology/physiopathology
Evry-Val-d’Essonnes University – Paris Saclay University
Evry-Val-d'Essonnes 09.2014 - 01.2019
Skills
hPSC reprogramming & culture
hPSC differentiations
Primary cell culture
IHC
PCR/qPCR
Western Blot
Flow cytometry
Animal experiments
Students training
Research design
Lab management
Time management
SOPs
GraphPad Prism
Team working
Dedicated
Hardworking
Problem solving
Initiative
Timeline
Research Officer 3
Children Medical Research Institute
01.2022 - Current
Research Officer 1
Brainever – Collège de France
01.2020 - 01.2021
Ph.D. - Physiology/physiopathology
Evry-Val-d’Essonnes University – Paris Saclay University
09.2014 - 01.2019
PhD Fellowship
PHENOCELL – I-STEM
01.2014 - 01.2019
Research Assistant
INSERM
01.2013 - 01.2014
Research Internship
Sanofi
01.2013 - 12.2013
Research Internship
Theranexus – CEA
01.2011 - 12.2012
Languages
French
Native or Bilingual
English
Full Professional
Personal Information
Visa Status: 482 Visa – full working rights in Australia
COMMUNICATIONS
ORAL COMMUNICATIONS:
- 2023 - Brussels (Belgium) - ESCGT - Gene editing for Usher Syndrome type 2A: Unravelling photoreceptor degeneration mechanisms & exploring therapeutic potential. Deborah Aubin
- 2019 - Evry (France) - PhD defense - Modeling NF1 osteoblast differentiation impairment using human pluripotent stem cell. Deborah Aubin
- 2018 - Paris (France) - Cochin hospital - Modeling NF1 osteoblast differentiation impairment using human pluripotent stem cell. Deborah Aubin
POSTER COMMUNICATIONS:
- 2024 - Adelaide (Australia) - ASSCR - Gene editing and disease mechanisms for Usher Syndrome type 2A. Deborah Aubin, Hani J. Kim, Adrian Westhaus, Victoria Nemeruck, Pengyi Yang, Leszek Lisowski, Anai Gonzalez-Cordero.
- 2023 - Sydney (Australia) - ASSCR - Gene editing and disease mechanisms for Usher Syndrome type 2A. Deborah Aubin, Hani J. Kim, Adrian Westhaus, Victoria Nemeruck, Pengyi Yang, Leszek Lisowski, Anai Gonzalez-Cordero.
- 2023 - Gold Coast (Australia) - ISER - Disease modelling of Usher syndrome type 2 using hiPSC- derived retinal organoids. Deborah Aubin, Benjamin Lim, Emilie Wong, George Craft, Mark Graham, Anai Gonzalez-Cordero.
- 2022 - Melbourne (Australia) - ASSCR - Disease modelling of Usher syndrome type 2 using hiPSC- derived retinal organoids. Deborah Aubin, Benjamin Lim, Emilie Wong, George Craft, Mark Graham, Anai Gonzalez-Cordero.
- 2017 - Boston (USA) - ISSCR - NF1 bone lesions modeling using pathological hPSC. Developement of test study and drugs screening. Deborah Aubin, Gilles Lemaitre, Julien Maruotti, Brigitte Onteniente.
- 2016- Padova (Italy) - European Neurofibromatosis Meeting - Schwann cell differentiation protocol from hiPSC for the study of neurofibroma development in NF1 disease. Deborah Aubin, Gilles Lemaitre, Julien Maruotti, Brigitte Onteniente.
PUBLICATIONS
- Satheesh Kumar, Yi-Wen Hsiao, Vickie H Y Wong, Deborah Aubin, Jiang-Hui Wang, Leszek Lisowski, Elizabeth P Rakoczy, Fan Li, Luis Alarcon-Martinez, Anai Gonzalez-Cordero, Bang V Bui, Guei-Sheung Liu. (2024). Characterization of RNA editing and gene therapy with a compact CRISPR-Cas13 in the retina. PNAS, 121(45):e2408345121. DOI: 10.1073/pnas.2408345121.
- Annabelle Darle, Thibault Mahiet, Deborah Aubin, Manon Doyen, Lina El Kassar, Béatrice Parfait, Gilles Lemaitre, Christine Baldeschi, Jennifer Allouche, Nathalie Holic. (2024). Generation of heterozygous and homozygous NF1 lines from human-induced pluripotent stem cells using CRISPR/Cas9 to investigate bone defects associated with neurofibromatosis type 1. Front Cell Dev Biol, DOI: 10.3389/fcell.2024.1359561.
- Reem Bou Akar, Chéryane Lama, Deborah Aubin, Julien Maruotti, Brigitte Onteniente, Joana Esteves de Lima, Frédéric Relaix. (2024). Generation of highly pure pluripotent stem cell-derived myogenic progenitor cells and myotubes. Stem Cell Reports. DOI: 10.1016/j.stemcr.2023.11.002.
- Carmen Capone, Emmanuel Cognat, Lamia Ghezali, Céline Baron-Menguy, Deborah Aubin, Laurent Mesnard, Heidi Stöhr, Valérie Domenga-Denier, Mark T Nelson, Anne Joutel. (2016). Reducing Timp3 or vitronectin ameliorates disease manifestations in CADASIL mice. Ann Neurol. DOI: 10.1002/ana.24573.