Currently pursuing a PhD in Drug Delivery at Monash University's Faculty of Pharmacy and Pharmacology Sciences. Research focuses on developing NIR-responsive linkers based on BODIPY scaffolds for targeted drug delivery using nanoparticle systems.
Overview
11
11
years of professional experience
Work History
PhD Student
Monash University
07.2023 - Current
Utilizing organic synthesis to develop cleavable linkers that responsible to exogenous stimuli like Near Infrared light or radio frequency.
Conjugating the exogenous stimuli cleavable linker to the nanoparticles like porous silicon nanoparticles or gold nanoclusters for better controlled drug release for cancer therapy.
Research Specialist
King Abdullah University of Science and Technology
01.2019 - 12.2020
Use LC-MS/MS techniques to analyze plant metabolism, including carotenoids, apocarotenoids, strigolactones, abscisic acid, etc
Three papers regarding these metabolisms have been published
Research Assistant
Macau University of Science and Technology
07.2017 - 08.2018
Organized protein pull-down assay from start to finish by designing an effective synthesis scheme for biotin probing and protein identification procedures
Five different biotin-based probes have been synthesized, and one potential binding protein has been identified
Master student
Macau University of Science and Technology
09.2013 - 02.2017
Use HPLC and Semi-HPLC to isolate and purify components from a Chinese herb
34 compounds have been identified and two compounds have been identified as anti-influenza viruses
Use Organic synthesis to synthesize 16 derivatives of Aurantiamide Acetate for the further mechanism study of their anti-influenza virus activity
Use Organic synthesis to synthesize 10 derivatives of Gensinoside Rb1 as standards for LC-MS analysis of rats' blood
Education
Ph.D. - Drug Delivery Disposition And Dynamics
Monash University
Parkville, VIC
12-2026
Master of Science - Pharmacology in Chinese Medecine
Macau University of Science And Technology
Macau
02-2017
Bachelor - Pharmacology in Chinese Medicine
China Pharmaceutical University
06.2013
Skills
Organic Synthesis: Expert in complex multi-step synthesis of chromophores and fluorophores, with proven skills in reaction optimization and mechanistic analysis Proficient in scaled-up synthesis and handling light-sensitive compounds
Nanoparticle Engineering: Specialized in bottom-up synthesis of gold nanoclusters and porous silicon nanoparticles, with expertise in surface functionalization and comprehensive characterization (DLS, TEM, SEM, UV-Vis)
Analytical Chemistry: Advanced proficiency in chromatographic analysis (LC-MS, GC-MS) for molecular identification and quantification, complemented by structural determination using FT-IR and multinuclear NMR spectroscopy
Computational Chemistry: Expert in quantum chemical calculations using GAUSSIAN, focusing on electronic structure analysis and modeling of organic dyes and nanomaterials
Publications
Zhou B, Yang Z, Feng, Q., et al. Aurantiamide acetate from baphicacanthus cusia root exhibits anti-inflammatory and anti-viral effects via inhibition of the NF-κB signaling pathway in Influenza A virus-infected cells [J]. Journal of ethnopharmacology, 2017, 199: 60-67. (Times Cited 49)
Zhou, B., Liang, X., Feng, Q., Li, J., Pan, X., Xie, P., ... & Yang, Z. (2019). Ergosterol peroxide suppresses influenza A virus-induced pro-inflammatory response and apoptosis by blocking RIG-I signaling. European journal of pharmacology, 860, 172543. (Times Cited 14)
Feng, Q., Zhu, G., Gao, W., et al. Two New Alkaloids from the Roots of Baphicacanthus cusia [J]. Chemical & pharmaceutical bulletin, 2016, 64(10): 1505. (Times Cited 16)
Mi, J., Jia, K. P., Balakrishna, A., Feng, Q., & Al-Babili, S. (2019). A Highly Sensitive SPE Derivatization–UHPLC–MS Approach for Quantitative Profiling of Carotenoid-Derived Dialdehydes from Vegetables. Journal of agricultural and food chemistry, 67(20), 5899-5907. (Times Cited 10)
Wang, J. R., Yau, L. F., Tong, T. T., Feng, Q., Bai, L. P., Ma, J., ... & Jiang, Z. H. (2015). Characterization of oxygenated metabolites of ginsenoside Rb1 in plasma and urine of rat. Journal of agricultural and food chemistry, 63 (10), 2689-2700. (Times Cited 12)
Ablazov, A., Mi, J., Jamil, M., Jia, K.P., Wang, J.Y ., Feng, Q. and Al-Babili, S., 2020. The Apocarotenoid Zaxinone Is a Positive Regulator of Strigolactone and Abscisic Acid Biosynthesis in Arabidopsis Roots. Frontiers in Plant Science, 11, p.578. (Times Cited 26)
Jia, K. P., Mi, J., Ablazov, A., Ali, S., Yang, Y ., Balakrishna, A., ... & Al-Babili, S. (2021). Iso-anchorene is an endogenous metabolite that inhibits primary root growth in Arabidopsis. Plant J, 10(10), 15271. (Times Cited 9)
Patent
Jing-Rong W, Jiang Z, Feng Q, et al. Method of isolating anti-viral ingredients from baphicacanthus cusia, compositions comprising them and their medical use: U.S. Patent Application US 2017/0281702. 2017-10-5.
Jiang Zhi-hong, Zhong Nanshan, Yang Zifeng, Wang Jing-Rong, Feng Qitong, et al. Compounds and methods for treating influenza, Australia Patent Application, AU 2020103878. 2021-01-27
Zifeng Yang, Beixian Zhou, Feng Q, et al. Application of peroxy-ergosterol in drug resisting influenza virus infection and preparation of peroxy-ergosterol; China Patent Application CN106432400A. 2017-02-22.
Zifeng Yang, Beixian Zhou, Feng Q, et al. Application of aurantiamide acetate in anti-influenza virus medicine and preparation of aurantiamide acetate; China Patent Application CN106431960A. 2017-02-22.
Jing-Rong W, Jiang Z, Feng Q, et al. Method of isolating anti-viral ingredients from baphicacanthus cusia, compositions comprising them and their medical use: U.S. Patent Application AU 2016100366 A4. 2016-5-12.
Jiang Zhi-hong, Zhong Nanshan, Yang Zifeng, Wang Jing-Rong, Feng Qitong, et al. Compounds and methods for treating influenza, U.S. Patent Application, US9345690B2. 2022-04-8.
Timeline
PhD Student
Monash University
07.2023 - Current
Research Specialist
King Abdullah University of Science and Technology
01.2019 - 12.2020
Research Assistant
Macau University of Science and Technology
07.2017 - 08.2018
Master student
Macau University of Science and Technology
09.2013 - 02.2017
Bachelor - Pharmacology in Chinese Medicine
China Pharmaceutical University
Ph.D. - Drug Delivery Disposition And Dynamics
Monash University
Master of Science - Pharmacology in Chinese Medecine
Macau University of Science And Technology
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